Top seed Daniil Medvedev (26) will open his US Open title defence against American Stefan Kozlov but faces major hurdles on the path to a second Grand Slam title at Flushing Meadows, including in-form Australian Nick Kyrgios (27).
While Medvedev will not be looking too far ahead, fans certainly will at the prospect of an enthralling fourth-round showdown between the Russian and Wimbledon finalist Kyrgios who beat the world number one in three sets in Montreal this month.
The bottom half of the draw also throws up a potential mouth-watering all-Spanish clash between second seed Rafa Nadal, bidding for a fifth US Open crown, and teenager Carlos Alcaraz, who last year became the youngest man to reach the quarter-finals at Flushing Meadows.
Nadal, who could leave New York with the world number one ranking if he can lift a 23rd Grand Slam trophy, will meet Australian Rinky Hijikata in the first round while third seed Alcaraz takes on Argentine Sebastian Baez.