Rodgers injured on Jets debut, coach fears Achilles damage
Rodgers, who joined the Jets after 18 seasons with the Green Bay Packers, was sacked by Bills defensive end Leonard Floyd with 11:15 left in the first quarter.
After briefly getting to his feet, he sat back down on the turf before being helped off the field. He was examined on the sidelines by team medical staff before heading to the locker room and did not return to the game.
"Concerned with his Achilles," Saleh told reporters after the game, which the Jets won 22-16.
"An MRI is probably going to confirm what we think has happened, so prayers tonight, but it's not good."
Rodgers has stirred excitement among Jets fans after his move in the off-season from the Packers, where he won four league MVP awards and led the team to a Super Bowl title in 2011.
"I hurt for Aaron and how much he has invested in all of this," added Saleh. "I'm still going to hold out hope. But my heart's with Aaron right now, nobody else."
Zach Wilson replaced Rodgers at quarterback and led the Jets to the win in overtime.