Serbian Djokovic is seeking a men's record-extending 24th Grand Slam title that would also draw him level with Australia's Margaret Court, to match Roger Federer's eight Wimbledons and equal Federer and Bjorn Borg's record of five successive men's singles crowns.
He took a convincing first step with a 6-3 6-3 7-6(4) victory where the only time he looked really inconvenienced was when complaining about the risk of slipping on a mildly damp court after a shower caused a 70-minute delay during which the roof was closed and reopened.
Last time Djokovic lost on Centre Court was in the 2013 final against Andy Murray and remarkably that was also his last defeat on grass by any of the 128 players in this year’s draw, though for several years he has avoided any of the grasscourt warm-up events.
"For me, the opening match is a little bit tricky, I've not played any warm-up match and grass is a little different to clay," Djokovic said.
"I've managed to adapt pretty well over the years and hopefully I manage to do it again."
Djokovic accepted that the rain delay was frustrating for the crowd but said it was still slippery until after the roof had been reopened. "I usually come out with rackets, not towels," he said.
SMALL MARGINS
As a reminder of the small margins that separate the great from the merely very good, Wimbledon debutant Cachin had played only one match on grass, and lost it, but for long spells went toe to toe with the most successful player of all time and broke him for a 3-2 first-set lead on a rare Djokovic double fault.
The champion broke back immediately, however, and when he began to find his range, battered his way through the Argentine’s defences to take the first set in 42 minutes.
Then followed the sort of delay that drives Wimbledon fans mad. After a mild shower, the roof was slid into place, but Djokovic was reluctant to return to the fray, pacing the court as ball boys took to using leaf blowers to dry the surface.
The action resumed after 70 minutes - with the roof open again - and Djokovic hit the ground running with an immediate break. While he threw in some crowd-pleasing drop shots, it was the relentless power and accuracy of his groundstrokes combined with an increasingly emphatic serve that wore down his 68th-ranked opponent.
To his credit, Cachin kept the champion honest in the third, coming back from 0-30 at 5-4 down with four straight points to take it to a tiebreak, but Djokovic merely went through the gears again to win it comfortably.
Tougher challenges will lie ahead in the next two weeks but, in the absence of the retired Roger Federer and injured Rafa Nadal, someone from the next generation is going to have to find something special to stop Djokovic from walking away with another armful of records.